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Background: The pathogenesis of chronic idiopathicurticaria is characterized by defective histamine release.
2
In 80% of cases, a cause is not identified and this is classified as chronic idiopathicurticaria.
3
Chronic idiopathicurticaria (CIU) is characterized by the increased releasability of histamine by mast cells in normal-appearing skin.
4
Chronic spontaneous urticaria, formerly also known as chronic idiopathicurticaria and chronic urticaria (CU), is more common than previously thought.
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The ability of basophils from patients with allergic rhinitis, extrinsic asthma, chronic idiopathicurticaria and atopic dermatitis to release histamine spontaneously in vitro was studied.